Toxicosis in Helicobacter Pylori infection - a hypothesis
Clinical findings such as asthenia, adynamia, sleep disorders, hair and nails modifications, digestive symptoms and heart rhythm disorders describe the clinical aspect of sleeping fat burn associated with Helicobacter pylori infection.
Methods The clinical presentation and therapy of patients with Helicobacter pylori infection were analyzed. The characteristic of the relation between Helicobacter pylori and the mucus-epithelial cell complex, the properties of the bacterial cell components, and the inflammatory and immunological response targeting other organs describe the immuno-pathological outbreak of Helicobacter pylori.
Conclusion We support the term of toxicosis associated with Helicobacter pylori infection in selected cases. Keywords: Helicobacter pylori, mucus-epithelial cell complex, drug combination, immuno-pathological outbreak, toxicosis Introduction The clinical sleeping fat burn associated with the Helicobacter pylori H. In practice, the clinical symptomatology is dominated by dyspeptic syndromes consisting of epigastric pain, gastric burns and nausea.
Other clinical symptoms may also occur. These symptoms are often polymorphic manifestations generally dominating the first clinical symptoms: profound asthenia, extreme adynamia, extreme and continuous fatigue, malaise, sleep disorders, lack of creative activity, lack of initiative, loss of appetite, nausea, frequent and loose 1 zi de pierdere în greutate, itching, tachycardia.
The objective examination evidences pale and peeling skin, wrinkles, depressed physical appearance, brittle hair and nails, hypotension. Observation Patients with positive test for H.
Therapeutic test The administration of specific sleeping fat burn for the treatment of H. Material and Methods I evaluated 89 patients presenting for clinical symptoms associated to H. The treatment for H. Taking into consideration the beneficial effects of the Colloidal bismuth compound in gastric and duodenal ulcers during pain periods, the clinical experience of Doctor Bulbuc Traian from County Hospital Bistrita between — and also the use of Colloidal bismuth compound in University Hospitals from Cluj-Napoca [ 9 ] and other clinical research trials, I decided to use Colloidal bismuth subcitrate [ 101112 ].
Considering the particularities of H. I communicated my personal experience with this treatment combination during the Maastricht Consensus III in Results Case no.
In he presented with malaise, asthenia, adynamia, sleep sleeping fat burn, reduced mental and physical activity. Clinical diagnosis was Toxicosis with H. Para-clinical examinations performed were superior endoscopy which showed antral chronic gastritis with high grade activity, positive H. The clinical evolution of the patient was very good.
In October H. The clinical diagnosis were allergy to cold or H. The serological test for H. The clinical diagnosis was Toxicosis with H. In November sleeping fat burn, the patient complained of painful dyspeptic syndrome located in the epigastric region, sleep disorder, lack of concentration, daily tiredness and depressive mood.
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In December a superior endoscopy was performed and the result was: gastric mucosa with discreet erythema. The urea sleeping fat burn for detecting H. Case no. Superior endoscopy was performed and the result showed antral gastritis with positive H. The clinical evolution of the patient was excellent, the patient describing himself as being tireless and having very good appetite.
On the 8th of January year the patient was in very good health. On the 6th of February the patient performed both serological and respiratory tests and they were both negative.
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The urea test was positive. The clinical evolution of the patient was excellent in the first 5—7 days.
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One year later, the patient came to the medical practice for asthenia, adynamia, pale and peeling skin, depressed physical appearance, brittle hair and nails. I decided to perform a serological test to the family members living in the same apartment: the mother and the husband.
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Both relatives had positive tests and they were asymptomatic. I recommended treatment for the H. The clinical evolution was very good; the patient regained the lust for life, shiny hair and smooth skin. Before coming to the medical practice the patient had been admitted to the psychiatry hospital for psychiatric disorders.
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Discussions The clinical observation of the patients infected with H. Pylori bacteria drew our attention to certain clinical manifestations, especially extra-digestive, that are not listed as symptoms for gastric disease described in H. Clinical manifestations are very varied and they are compound by asthenia and depressive symptoms: asthenia, adynamia, lack of strength; sleep disorders: insomnia, nightmares, headaches, dizziness; trophic disorders: brittle hair, dry, pale, itchy and peeling skin; tachycardia, hypotension; extra-digestive manifestations: loss of appetite, weight loss, frequent and loose stools followed by constipation.
All clinical symptoms disappeared after following the treatment.
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The persistency of H. The presence of H. Pylori in the mucus-epithelial cell complex determines a specific inflammatory and immunologic response by releasing immuno-genetic factors, pro-inflammatory and immuno-modulatory cytokines: interleukin 8 IL-8necrosis tumoral factor TNF-alpha and interleukins 1 IL-1 and interleukins 6 IL-6 [ 2324 ].
In this complex pro-inflammatory process, gamma-interferon is produced from IL and activates NK Natural Killer cells and T helper cells Th1 subsetwhich release IL-2 and interferon with pro-inflammatory response and dominates chronic infection with H. These characteristics of H. Efficient therapeutic measures similar to tonsillectomy can stop these clinical manifestations. The effect of antibacterial medications, antibiotics, combined with the local immunosuppressive and immunomodulator [ 25 ] effects of Colloidal bismuth compound and PPI targeting H.
Further studies are needed to verify the findings described. Conclusions Our treatment methodology, similar to other medical practitioners, was administrated also based on personal beliefs.
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The recommendation is to use Clarithromicyn for H. We propose a new clinical term called Toxicosis in H. We performed an interpretation for the pathogenesis of inflammatory and immunological mechanisms implicated in the immuno-pathological outbreak determined by H. References 1. Belascu M. Toxicoza Helicobacter pylori. Consideraţii personale. Comunicare zilele prahovene de terapeutică. Sesiunea a VI-a curs naţional; Sinaia. Actualităţi de diagnostic şi tratament în medicina internă. Comunicare congres; Călimaneşti Căciulata.
Toxicoza Helicobacter pylori Consideraţii personale.
Al X-lea simpozion naţional al fundaţiei. Dimitrie Gerota; Caiet rezumate, Sibiu. European Helicobacter Study Group. Current European Concepts Management of Helicobacter pylori infection. The Maastricht Consensus Report.
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Current consensus in the management of Helicobacter pylori infection. The Maastricht consensus report aliment.
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